Ellagic Acid
Ellagic acid is a naturally occurring polyphenolic constituent found in 46 different fruits and nuts such as grapes, pomegranate, red raspberry, strawberry, blueberry, and walnuts.
Ellagic acid enhances the activity of certain detoxification enzymes in the liver, speeding up the removal of dangerous substances from the body, while it also inhibits the cytochrome P450 liver enzymes and may prevent them from metabolizing carcinogens into more dangerous forms. Second, ellagic acid causes changes in the cell cycle of cancer cells in the test tube, leading to cell death.
“[Ellagic acid] prevents the binding of carcinogens to DNA and strengthens connective tissue, which may keep cancer cells from spreading.” (1) Ellagic Acid has the ability to inhibit mutations within a cell's DNA. Furthermore, it is considered to be a cancer inhibitor which has the ability to cause apoptosis or normal cell death in cancer cells.
First, ellagic acid kills cancer cells:
Healthy cells have a normal life cycle of approximately 120 days before they die. This process is called apoptosis (natural cell death). The body replaces these dying cells with healthy cells. Conversely, cancer cells do not die. They multiply by division, making two cancer cells, then four, eight, 16, 32 and so on. In lab tests, Ellagic Acid caused the cancer cells to go through the normal apoptosis process without damaging healthy cells. Chemotherapy, radiation and most conventional treatments cause the death of cancer cells and healthy cells indiscriminately, possibly destroying the immune system in the process. Ellagic Acid is clearly the sensible choice. (2)
Second, ellagic acid stops the growth of tumors:
Rats that consumed 5-10 percent of their diet as freeze-dried black raspberries and strawberries showed dramatic reductions in the growth of precancerous cells and tumor progression, the researchers found. And in other animal tests, Stoner told Reuters Health, the berries reduced colon cancer growth by 80 percent. The Ohio Department of Agriculture supported the research Stoner presented at the meeting. (2)
Third, ellagic acid causes G-arrest:
The Hollings Cancer Institute at the University of South Carolina has conducted a double blind study on a group of 500 cervical cancer patients that had everyone excited. Nine years of study have shown that a natural product called Ellagic acid is causing G-arrest within 48 hours (inhibiting and stopping mitosis-cancer cell division), and apoptosis (normal cell death) within 72 hours, for breast, pancreas, esophageal, skin, colon and prostate cancer cells. (3)
Fourth, ellagic acid helps prevent cancer, birth defects, etc.
European medical studies also demonstrate that Ellagic Acid is known to lower the incidence of birth defects, promote wound healing, reduce heart disease, and may reduce or reverse chemically induced liver fibrosis. (4)
Fifth, ellagic acid does a lot of other good things:
From Dr. Glen Halvorson's Book, Chemopreventive Properties of …Phytochemicals, we learn that ellagic acid is antibacterial, [it] destroys the H. pylori bacteria responsible for stomach ulcers, [it] protects the liver and liver function, [it] binds with carcinogens (chemicals that cause cancer) making them inactive, [it] prevents carcinogens from binding to DNA [and it] reduces glucose levels (aids in management of diabetes). (5)
Sixth, ellagic acid (i.e. from ellagitannins), is combined with glucose, making sure that cancer cells get a larger dose of ellagic acid than normal cells because cancer cells consume about 15 times more glucose than other cells. This means cancer cells probably get far more ellagic acid than normal cells:
Although ellagic acid is the bioactive agent that offers protection, the phytochemical is generally ingested in the form of another biochemical called ellagitannin. Plants produce ellagic acid and glucose that combine to form ellagitannins, which are water-soluble compounds that are easier for animals to absorb in their diets. Consequently, small amounts of ellagitannins derived from natural sources may be more effective in the human diet than large doses of purified ellagic acid. (6)
Here is how it works:
Ellagic Acid is a phenolic compound that has become known as a potent anti-carcinogenic/anti-mutagenic compound. It also has antibacterial and antiviral properties. Ellagic Acid itself is not thought to be naturally present in plants. Instead, polymers of gallic acid and hexahydroxydipenoyl (HHDP) are linked to glucose centers to form the class of compounds known as ellagitannins. When two gallic acid groups become linked side by side within a tannin molecule an HHDP group is formed. Ellagic Acid is the result when the HHDP group is cleaved from the tannin molecule and spontaneously rearranges. It is the ellagitannins that are present in red raspberries. (7)
At the current time, ellagic acid supplements are generally not used as a stand-alone treatment for cancer. Rather, ellagic acid supplements are usually used in conjunction with other treatments. However, ellagic acid is found in fruits and nuts that are part of major alternative cancer treatments, such as the grape cure, Budwig Flaxseed (when walnuts are used), the Raw Food diet, etc.
It would probably be a mistake to take ellagic acid supplements without also consuming many natural, whole, raw foods that contain ellagic acid in order to get necessary enzymes and other synergistic nutrients.
RESOURCES:
Ellagic acid enhances the activity of certain detoxification enzymes in the liver, speeding up the removal of dangerous substances from the body, while it also inhibits the cytochrome P450 liver enzymes and may prevent them from metabolizing carcinogens into more dangerous forms. Second, ellagic acid causes changes in the cell cycle of cancer cells in the test tube, leading to cell death.
“[Ellagic acid] prevents the binding of carcinogens to DNA and strengthens connective tissue, which may keep cancer cells from spreading.” (1) Ellagic Acid has the ability to inhibit mutations within a cell's DNA. Furthermore, it is considered to be a cancer inhibitor which has the ability to cause apoptosis or normal cell death in cancer cells.
First, ellagic acid kills cancer cells:
Healthy cells have a normal life cycle of approximately 120 days before they die. This process is called apoptosis (natural cell death). The body replaces these dying cells with healthy cells. Conversely, cancer cells do not die. They multiply by division, making two cancer cells, then four, eight, 16, 32 and so on. In lab tests, Ellagic Acid caused the cancer cells to go through the normal apoptosis process without damaging healthy cells. Chemotherapy, radiation and most conventional treatments cause the death of cancer cells and healthy cells indiscriminately, possibly destroying the immune system in the process. Ellagic Acid is clearly the sensible choice. (2)
Second, ellagic acid stops the growth of tumors:
Rats that consumed 5-10 percent of their diet as freeze-dried black raspberries and strawberries showed dramatic reductions in the growth of precancerous cells and tumor progression, the researchers found. And in other animal tests, Stoner told Reuters Health, the berries reduced colon cancer growth by 80 percent. The Ohio Department of Agriculture supported the research Stoner presented at the meeting. (2)
Third, ellagic acid causes G-arrest:
The Hollings Cancer Institute at the University of South Carolina has conducted a double blind study on a group of 500 cervical cancer patients that had everyone excited. Nine years of study have shown that a natural product called Ellagic acid is causing G-arrest within 48 hours (inhibiting and stopping mitosis-cancer cell division), and apoptosis (normal cell death) within 72 hours, for breast, pancreas, esophageal, skin, colon and prostate cancer cells. (3)
Fourth, ellagic acid helps prevent cancer, birth defects, etc.
European medical studies also demonstrate that Ellagic Acid is known to lower the incidence of birth defects, promote wound healing, reduce heart disease, and may reduce or reverse chemically induced liver fibrosis. (4)
Fifth, ellagic acid does a lot of other good things:
From Dr. Glen Halvorson's Book, Chemopreventive Properties of …Phytochemicals, we learn that ellagic acid is antibacterial, [it] destroys the H. pylori bacteria responsible for stomach ulcers, [it] protects the liver and liver function, [it] binds with carcinogens (chemicals that cause cancer) making them inactive, [it] prevents carcinogens from binding to DNA [and it] reduces glucose levels (aids in management of diabetes). (5)
Sixth, ellagic acid (i.e. from ellagitannins), is combined with glucose, making sure that cancer cells get a larger dose of ellagic acid than normal cells because cancer cells consume about 15 times more glucose than other cells. This means cancer cells probably get far more ellagic acid than normal cells:
Although ellagic acid is the bioactive agent that offers protection, the phytochemical is generally ingested in the form of another biochemical called ellagitannin. Plants produce ellagic acid and glucose that combine to form ellagitannins, which are water-soluble compounds that are easier for animals to absorb in their diets. Consequently, small amounts of ellagitannins derived from natural sources may be more effective in the human diet than large doses of purified ellagic acid. (6)
Here is how it works:
Ellagic Acid is a phenolic compound that has become known as a potent anti-carcinogenic/anti-mutagenic compound. It also has antibacterial and antiviral properties. Ellagic Acid itself is not thought to be naturally present in plants. Instead, polymers of gallic acid and hexahydroxydipenoyl (HHDP) are linked to glucose centers to form the class of compounds known as ellagitannins. When two gallic acid groups become linked side by side within a tannin molecule an HHDP group is formed. Ellagic Acid is the result when the HHDP group is cleaved from the tannin molecule and spontaneously rearranges. It is the ellagitannins that are present in red raspberries. (7)
At the current time, ellagic acid supplements are generally not used as a stand-alone treatment for cancer. Rather, ellagic acid supplements are usually used in conjunction with other treatments. However, ellagic acid is found in fruits and nuts that are part of major alternative cancer treatments, such as the grape cure, Budwig Flaxseed (when walnuts are used), the Raw Food diet, etc.
It would probably be a mistake to take ellagic acid supplements without also consuming many natural, whole, raw foods that contain ellagic acid in order to get necessary enzymes and other synergistic nutrients.
RESOURCES:
- Healthy Eating to Combat Diseases – By Sandra Tay
- http://www.oregon-berries.com/cx15/sx-rx-haltcancer.pdf
- http://www.ellagic.net/
- http://www.hopeforcancer.com/Ellagic.htm
- Chemopreventive Properties of Phytochemicals by Dr. Glen Halvorson
- http://micro.magnet.fsu.edu/phytochemicals/pages/ellagicacid.html
- http://www.ellagic-research.org/summary.htm
Published Research:
Main components of pomegranate, ellagic acid and luteolin, inhibit metastasis of ovarian cancer by down-regulating MMP2 and MMP9.
https://www.ncbi.nlm.nih.gov/pubmed/29173024
https://www.ncbi.nlm.nih.gov/pubmed/29173024
Benefits of ellagic acid from grapes and pomegranates against colorectal cancer.
https://www.ncbi.nlm.nih.gov/pubmed/28932378
https://www.ncbi.nlm.nih.gov/pubmed/28932378
Ellagic Acid Holds Promise Against Hepatocellular Carcinoma in an Experimental Model: Mechanisms of Actionhttps://www.ncbi.nlm.nih.gov/pubmed/29479987
Direct inhibition of ACTN4 by ellagic acid limits breast cancer metastasis via regulation of β-catenin stabilization in cancer stem cells.
https://www.ncbi.nlm.nih.gov/pubmed/29197410
https://www.ncbi.nlm.nih.gov/pubmed/29197410
Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo.https://www.ncbi.nlm.nih.gov/pubmed/18202771